![]() Justin McAnear, 10x's CFO, attributed the rise in spending to higher personnel-related costs.įor full-year 2022, 10x's revenues increased 5 percent to $516.4 million from $490.5 million, beating the average Wall Street estimate of $$508.1 million.įull-year consumables revenues were $435.6 million, up 4 percent year over year from $418.7 million in 2021 instrument revenues were $72.4 million, up 12 percent from $64.5 million and service revenues were $8.4 million, up 16 percent from $7.3 million.īy region, revenues from the Americas were $293.8 million in 2022, up 11 percent year over year revenues from Europe, the Middle East, and Africa revenues were $117.1 million, up 8 percent year over year and revenues from Asia-Pacific were $105.6 million, down 10 percent from 2021. ![]() Its SG&A expenses rose 13 percent to $78.9 million from $69.9 million. The firm's Q4 R&D expenses rose 3 percent to $63.6 million from $61.9 million a year ago. The company's net loss for the quarter was $17.2 million, or $.15 per share, compared to a loss of $18.4 million, or $0.16 per share, in Q4 2021, and beating the average Wall Street estimate of a $0.31 loss per share. However, revenues from Asia Pacific were $27.6 million, down 13 percent year over year, primarily due to COVID disruptions. Revenues from Europe, the Middle East, and Africa totaled $43 million, up 24 percent year over year. ![]() Q4 revenues from the Americas were $85.6 million, up 11 percent year over year. Service revenue increased 29 percent to $2.3 million from $1.8 million in Q4 2021. 31, 2022, the Pleasanton, California-based single-cell and spatial technologies firm reported revenues of $156.2 million, up from $143.5 million during the prior-year period and beating the average Wall Street estimate of $148.7 million.Ĭonsumables revenues in the fourth quarter were $131.6 million, up 8 percent from $122.4 million, a year ago, while instrument revenues grew 15 percent year over year to $22.3 million from $19.4 million. The upgradable Chromium iX can process tens of thousands of cell per run.ġ0x Genomics reported after the close of the market on Wednesday a 9 percent increase in fourth quarter revenues, driven by consumables sales and partially offset by a decrease in revenues in China.įor the three months ended Dec. ![]() Last year, 10x announced that this assay will only be available on the Chromium X series instruments and later dropped the price of a Chromium Controller to $35,000 in coordination with the launch of the X series. "If you want to do straight up gene expression, Flex should be the default choice," Saxonov told GenomeWeb last week at the Advances in Genome Biology and Technology conference. The move comes as the firm is trying to make its Flex assay the go-to product for single-cell gene expression analysis using Chromium. In an email, a 10x spokesperson said the firm is committed to supporting the Chromium Controller installed base for "several years," and suggested that the Chromium iX instrument would become "a reasonable entry point moving forward." "In fact, after several consecutive quarters of customers overwhelmingly opting for X Series instruments, we made the decision during Q4 to discontinue future sales of our legacy Chromium Controller." " Throughout the year, we've seen ongoing demand for Chromium X Series instruments as both new and existing customers chose the X Series for its high performance, extended capabilities, and series-specific assets," 10x CEO and Cofounder Serge Saxonov said on a conference call with investors following the release of the firm's Q4 and full-year 2022 financial results. NEW YORK – 10x Genomics will be discontinuing its base model of the Chromium single-cell sample preparation instrument, the company said on Thursday. This article has been updated with information from 10x Genomics' earnings call.
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![]() ![]() The trial randomized 18,201 patients with nonvalvular Afib to take apixaban or warfarin. The ARISTOTLE trial was a multicenter, double-blind, comparative trial. In patients with Afib, apixaban has been shown to be better than warfarin at reducing the risk of stroke. “Apixaban has been shown to cause less major bleeding in patients compared to warfarin,” explained Fanikos, citing the ARISTOTLE trial. ![]() Fibrin creates a weblike structure that catches blood platelets and other molecules, which then bind together to form a blood clot.Īpixaban is just as effective, if not more so, than warfarin. Interrupting the clotting cascade ultimately stops a structure called fibrin from forming. They bind to factor Xa and stop it from continuing the clotting process,” explained John Fanikos, RPh, MBA, Director of Pharmacy Services for Brigham and Women’s Hospital. “The factor Xa inhibitors interrupt the process that allows blood to clot, known as the clotting cascade. The FDA first approved the drug in December 2012 and then signed off on a generic formulation in December 2019.Īpixaban is a direct factor Xa inhibitor. Patients are generally prescribed 5 mg or 2.5 mg doses, which can be taken with or without food. ![]() Apixaban comes in a tablet form and should be taken twice a day. DOACs include apixaban, betrixaban, dabigatran, edoxaban, and rivaroxaban.Īpixaban (Eliquis ®), is an anticoagulant that reduces a patient’s risk of developing a blood clot, which can cause deep vein thrombosis (DVT), pulmonary embolism (PE), and stroke from atrial fibrillation (Afib). DOACs are as effective and safer than warfarin, especially with regard to serious bleeding episodes. For the past several decades, warfarin has been the go-to anticoagulant (sometimes called a blood thinner), but newer treatments have emerged in the form of direct oral anticoagulants (DOACs). ![]() ![]() ![]() However, Doncic averaged over three assists more than MJ's 4.8. In his first four seasons, MJ averaged a shade under 31 a game, leading Doncic by about four and a half. In rebounding, Doncic again takes the lead with 8.5 to Brons 6.7.Īgainst Jordan, Doncic did not fare so well in the scoring column. But he's averaged eight assists through four seasons while James averaged only 6.5 at the same point in his career. So let's jump the gun and see how he stacks up to the two greatest players in the history of the NBA, Michael Jordan, and LeBron James.Ĭompared to James, Doncic has a similar points-per-game average at this stage of their careers, 26.7 to 26.4. Doncic is already too good to be compared to his young peers and even all but the top four or five players in the league right now. Despite this, Michael Jordan is still competitive and outperforms James in some areas.Luka Doncic just wrapped up his rookie contract and fourth NBA season, and boy, has it been a spectacular start. ![]() Although they have nearly equal career averages, LeBron James has 4 more seasons of experience. When comparing their career averages, Michael Jordan averages 3 more points, 1 more steal, but also 1 fewer assist, 2 fewer rebounds, and the same number of blocks per game. The Goat □□ Michael Jordan 30 x 40 Acrylics on Canvas /4tKcpQfLKVĪlthough LeBron James outperforms Michael Jordan in most statistical categories, Lebron James has the advantage of having played in the NBA for four additional seasons. In addition, only Michael Jordan out of the two has won Defensive Player of the Year (winning it in 1988). While LeBron has four MVPs, Michael Jordan has five. Lebron just has one scoring title compared to MJ’s ten. LeBron has four final MVPs to Jordan’s six. Lebron James only has four championships, whereas Michael Jordan has six. The best way to evaluate these two careers could be to look at and contrast their awards and accomplishments. James: Playoff advanced stats Jordanĭruski chooses LeBron James over Michael Jordan as GOAT because of his support to Black community Michael Jordan was to basketball □ what Bruce Lee was to martial arts □ #BruceLee #MichaelJordan #GOAT□ Stop the debate and accept the TRUTH!!!✍️□□ /wUBY88TiE6 Lebron James is the GOAT of basketball□. LeBron James: Regular season advanced stats Jordan LeBron James: Regular season stats Jordan Michael Jordan on the Wizards might be my favorite way to play as MJ because his game has to be so grounded that you got to really pick and choose how to attack #SimNation #NBA2K23 #GOAT□ /RVThRXG8cG LeBron James has won more games, but Michael Jordan has a higher win %. With 1,072 games played, he has a 706-366 career record. Michael Jordan, meanwhile, has prevailed in 65.9% of his contests. LeBron James has participated in 1,371 regular season games, winning 65.4 percent of them. Michael Jordan Vs LeBron James: Who’s The Goat? Who Won More? The King is starting to become the undisputed GOAT □ /o8LhjQkFp0 LeBron James will probably end the season 1st all-time in points, 4th all-time in assists and 8th all-time in steals… LeBron James GOAT controversy and the extent of each player’s achievement. Join us as we explore the Michael Jordan vs. LeBron eventually entered the main league and even wore the number 23 so it was only a matter of time. For starters, he mimicked him in terms of clothing, footwear, and even pitching techniques. ![]() ![]() And while a detailed comparison of LeBron James’ stats to those of Michael Jordan is necessary, it is only fair to remark that both players are exceptional.ĭespite comparisons between the two, LeBron grew up idolising Michael Jordan. As far as NBA is concerned, there have been several discussions regarding whether LeBron James can topple Michael Jordan as the greatest player of all time ever since he was called The Chosen One. ![]() ![]() ![]() Safe for color- and chemically-treated hair. Ideal for wavy, curly, coily, and kinky hair patterns and coarse, thick, and thin textures. AG Care Re:Coil Curl Activator Curl Cream with Keratin Amino Acids - Ultra-Nourishing Curly Hair Cream for Defined, Healthy Curls, 12 Fl Oz 40.00 (3. This high-powered, lightweight curl-activating cream makes styling a breeze. Silk and keratin proteins – add moisture, strength, elasticity and shine. Achieve high-definition, frizz-free, silky curls with AG Cares expertly crafted superfood formulas.Natural herbal extracts including chamomile, wild cherry bark extract, hops, nettle, rosemary leaf and sage leaf extracts – soothe the scalp and add shine to hair.This product is specially designed to increase the curls and volume to hair. NaPCA – a powerful, natural moisturizer. AG Hair Recoil Curl Activator is the best hair moisturizing curl activator.It gently supports curls without being crunchy and helps give hair a silky, soft feel with lots of movement. ![]() Sulfate-free Shampoo AG Hair Cosmetics Recoil Curl Activating Shampoo Alba.
![]() ![]() Amplification Laney Pro Bass amp Used throughout the Bleach era. Boss DS-1 On occasion in late 1992 Krist would use Kurt's old DS-1s (after Kurt made the switch to the Boss DS-2) For later tours he requested the return of the Rat. ProCo Rat Distortion Krist's distortion pedal of choice. Effects MXR Distortion+ Used during the Bleach era. Gibson Hummingbird acoustic guitar, in Cherry Sunburst Another from the MTV Unplugged session, Krist used this on the Meat Puppets numbers. in New York, Krist didn't have an "unplugged" bass of his own. Guild B30E semi-acoustic bass Used at the MTV Unplugged session. Gibson EB-2 Krist also had a 1960s Pelham blue Gibson EB-2 bass on the In Utero tour, I've seen photos of him with it in a songbook somewhere…. Gibson RD Standard, in Ebony I gave this to Krist as a Kristmas present, he used it at the festival shows in Brazil. I converted the Ebony bass from black to chrome hardware, and Krist eventually gave it to Matt Lukin of Mudhoney in 1994. Gibson Thunderbird IV Krist had two T-Birds, one in Vintage Sunburst and the other in Ebony. Krist phoned to ask if I had any cool '60s basses for the shoot and I remembered still having the Ampeg that I played back in the early '80s. Ampeg AEB-1 The In Bloom video was to look as if it were filmed in the mid '60s and to have that kind of British invasion quality to it. Krist's could have likely bore the Silvertone label, but it's hardly worth getting too wrapped up in as it may have been bought an hour before it was destroyed! Warwick Dolphin Played in Holland at the 2 Meter Sessie the band used instruments supplied by the studio, as their own gear was being set up for a concert later that evening. Zen-Ons were sold in the US and Europe, like many '60s Japanese made guitars, under many different names depending on the importer. I'm not sure how he got it but probably bought the day of the shoot in L.A. '60s Japanese Zen-On Can been seen in the Smells Like Teen Spirit video. ![]() Gibson RD Artist, in Ebony Krist had two RD Artists that he toured heavily. Krist's Sunburst finish Ripper can be seen in the Come As You Are video An Ebony model can be seen in some of the footage used for the Sub Pop In Bloom video (you may also have seen one smacking Krist in the face at the 1992 MTV Video Music Awards!). Gibson Ripper Krist had at least two of each in Ebony and Natural finishes, and another in Sunburst. ![]() Unknown P/J bass Played at Lee's Palace in Toronto this bass was lent to Krist by Bruce Gordon of Rocktopus. Fender Precision Played and then smashed at the Kennel Club. '62 Fender Precision Played at the Kennel Club Krist borrowed this bass from Kurt Danielson of TAD. Gibson Victory, in Silver Played and smashed at the Riverside in Newcastle upon Tyne, the first night of the Bleach God's Balls tour. Krist's original Black Eagle is on exhibition at the Experience Music Project/Museum of Pop Culture. One can be seen in the Sliver video and parts of the footage used for the Sub Pop In Bloom video. These basses were frequently toured throughout the band's career. Ibanez Black Eagle 2609B Krist had 3–4 these, one of which I modified to have a rosewood neck. Guitars Ibanez Roadster Shown in that very early photo of Krist with his tongue out. Strings Rotosound Bass Strings Krist used Rotosound strings, RS66 Long Scale, Standard Gauge. ![]() ![]() ![]() Find out more about our advertising opportunities. Advertise Advertising on is well-targeted, has unique benefits, and is highly successful. Looking for something lighter? Read our funny complaints to see people who found humor in a bad situation. Vehicle Problems Find out what cars to avoid, view the latest problem trends, or keep up-to-date with the most recently reported problems. Contact us with any comments or concerns. Car Problem Resources Around the Site Information Find out more about us in the press or read stories from drivers who praise our work.The complaints are organized into groups with data published by vehicle, vehicle component, and specific problem. When I contacted Kia's corporate head quarters directly I was told that they could not do anything because the district manager had inspected the car and made the final decision.Ĭ ® is an online automotive complaint resource that uses graphs to show automotive defect patterns, based on complaint data submitted by visitors to the site. For instance, a cooler part that ?may" have metal particles in it, has to be replaced and was priced at $400. I consider this to be a defect in the car. I think purchasers should be aware of this. ![]() Are Kia owners not supposed to try to get to work if it snows. Never would I think that a new car would be destroyed that easily, nor do I think that it is right for the dealer to say it is all my fault. Never did I have a trouble with the transmission. I had to push it out of a snow drift, spun the tires. It had gotten stuck in the snow several times when I lived in Ohio. ![]() My argument is that I have had other cars, a Saturn for instance with close to 100K miles on it. Does this mean that anyone living where it snows should not by a Kia" I am aware of the stipulation in the warranty that the warranty does not cover damage done by snow, ice, road debris etc. I live in northern Kentucky so I get snow occasionally. After pushing for a short time transmission burned up and is now destroyed. We had to push the car out of the street. In December of 2004 with only 23,000 miles on it, it got stuck in the snow in the road blocking traffic. When we bought the car in December of 2003 it had only 79 miles on it. Depending on the dipstick, the markings can vary, but if it reveals you have enough transmission fluid, then you are good to go.We have a 2003 Kia Spectra. Use the funnel and add the transmission fluid.ħ) Once the transmission is filled, put the dipstick back in.Ĩ) Start your vehicle and let the engine run for about a few minutes to reach the optimal operating temperature.ĩ) When the transmission fluid is warm, check the fluid level with a dipstick. Let's learn how to change the automatic transmission fluid step by step.ġ) Jack your vehicle up to locate the transmission fluid drain plug beneath your car.Ģ) Put a catch pan under it and carefully loosen the drain plug to allow the fluid to drain.ģ) With the fluid drained, put the drain plug back in its place with a wrench.Ĥ) To refill your transmission fluid, check your owner's manual and it will specify which product you should use.ĥ) To know the correct amount of the fluid you should put in, use a translucent bottle with the measurements on its side to know how much fluid you need.Ħ) Refill your transmission fluid through the dipstick hole. The process of changing your transmission fluid is similar to changing your engine oil. Also, at the bottom of the dipstick, there are the minimum and maximum markings, so you can check the fluid level as well. If the fluid has gotten darker or looks dirty, it's probably time to change the fluid. Take the dipstick out of the tool and wipe it with a clean towel to see its fluid state. First, locate the transmission dipstick while the engine is running. Nevertheless, if you are doing the transmission fluid check on your own, you can take the simple steps as follows. However, under severe usage conditions, it needs to be replaced about every 90,000km(60,000 miles). Visit an authorized dealer/service partner for a more accurate transmission fluid check. ![]() To know when to check your transmission fluid, you need to check your owner's manual, but generally speaking, it doesn't need to be checked or serviced under normal usage conditions. So, having your transmission fluid checked by a professional mechanic is good for your transmission system. As it circulates through the parts, it can pick up dirt and metal debris over time. Transmission fluid plays a crucial role in lubricating the components of your transmission and prevents wear and tear of the parts. Air filter change interval, every 30000 km / 2 years Automatic gearbox oil change interval, every 60000 km / 4 years Brake fluid change interval, every 2. ![]() ![]() Turkish authorities have recently taken steps aimed at reining in chronic high inflation and reducing domestic demand, with the central bank hiking interest rates by 900 basis points in two months alongside other tightening measures. The BDDK also said in a statement late on Monday that it had decided to increase the risk weightings taken into account in calculating capital adequacy standard ratios for consumer loans, personal credit cards and vehicle loans. ![]() Polatoglu forecast a sharp fall in the numbers going abroad after a surge in spending by Turkish citizens abroad in the first half of the year to $3.17 billion – an 84% increase from the same period in 2022 – with such spending facilitated by credit card outlays. “The logic (of the step) is ‘citizens shouldn’t go abroad and spend foreign currency’,” he said, adding that the foreign travel sector was also being hit by increasing difficulties faced by Turks in securing tourist visas. “The number of people who can pay this amount in one go is very few.” ![]() “Almost all of my clients were paying by instalments,” said Cem Polatoglu, spokesman of a tour operators’ platform, noting an average trip for two cost around 50,000 lira ($1,850). Watch or download premium porn videos at full length for free. Tourism operators say they have been hit in recent years by a cost-of-living crisis and weakness in the lira, which has lost half its value against the dollar since end-2021, with travellers commonly using credit cards to finance trips. Watch full length Money Talks Serve It Up for free at Goodporn.to. ![]() The move, which hit airline shares and was seen as curbing foreign currency outflows, was one of two measures announced by the BDDK watchdog late on Monday, which it said were among coordinated steps to strengthen financial stability. ISTANBUL, (Reuters) – Turkey’s banking watchdog has stopped allowing credit card payments by instalment for foreign travel, such as flights, travel agency fees and accommodation, in a step seen dealing a blow to foreign travel operators. ![]() ![]() ![]() It's a great activity for kids interested in animals and nature and makes a thoughtful gift for someone else. Making a squirrel feeder is an easy, inexpensive project that will give you years of enjoyment. There are many kinds of squirrel feeders available at pet stores and online shops, but making one yourself is more eco-friendly and less expensive. Giving them food will help keep them fed and out of the garden. Squirrels are a common sight in almost all gardens, but they can be a bit of a nuisance when it comes to eating your harvest. 5 Ways To Make A Squirrel Feederĭo you have lots of squirrels in your lawn and garden? If so, you will find these easy DIY corn feeders for squirrels useful. You can make the perfect accessory for your backyard or patio to hang on trees, like an outdoor hanging shelf with accurate measurement and cutting. This design uses a 5" cedar board, hinge, and high-quality pixel glass to complete the piece. There are many DIY Squirrel Feeders that people make for both the squirrel and themselves. The squirrel feeder is an amazing design that the squirrels can open their way in to feed. Then, you should place a bowl upside down and then place another board on top of it. Once you have made this all up, it is time to drill holes at regular intervals on the top face of the wooden board. Additionally, you must ensure that the woods are perpendicular with a screw on the base for corn to fit in. In order to make a squirrel feeder, a person needs to use a radial arm or table saw or hand-saw and chisel. Go through our list and pick your preferred squirrel feeder! How To DIY A Squirrel Feeder Lastly, these squirrel feeders also come with detailed plans that you can use to follow step-by-step instructions on how to build them. Moreover, they do not require a lot of space as most of them can be built in an indoor setting. However, there are some that do not need you to make use of any tools. Most squirrel feeders require little or no woodworking experience and are beginner-friendly projects. DIY Squirrel Feeder PlansĬheck out this ultimate guide of 25 DIY Squirrel Feeder Plans to help you keep squirrels away from your garden, seedlings, and fruits while feeding them simultaneously. All these projects are beginner to intermediate-level woodworking projects that can be completed in two hours or less. If you are looking for DIY squirrel feeder plans, we have done all the hard work to compile a list of delicious and easy-to-make feeders that squirrels will go crazy after. This article will provide some of the best DIY Squirrel Feeder Plans. However, if you want your squirrels to have a place to relax and eat without worrying about getting inside the house, you should invest in an open-air planter known as a squirrel feeder box. ![]() This can be done in the form of specialized gourds, hangers, and many other types of feeders. Most squirrel feeders need you to add a food source, either seed or nuts. ![]() ![]() ![]() ![]() Don’t hide behind ambiguous wording such as “reasonable” or “best efforts” unless it is necessary (and sometimes it will be!). Set objective standards to determine whether or not a breach occurred. The contract should include a “Notice and Opportunity to Cure” clause.Ĭonsider drafting a section that obligates the non-breaching party to notify the breaching party in writing of his breach, allows a certain period (30 days, for example) for him to “cure” (rectify) his breach, and provides that the non-breaching party has the right to terminate the contract if the breaching party has not cured his breach within the specified time frame. Use “Including but not necessarily limited to” language, if appropriate, to prevent one party from arguing that his breach was not material simply because his action was not specifically listed in the contract. ![]() Include a carefully drafted section that lists specific acts and omissions and identifies them as material breaches justifying termination of the contract. The contract should provide a detailed list of “material” breaches. Unfortunately, despite this definition, a certain amount of ambiguity remains concerning whether or not a particular breach is “material.” The following contract drafting guidelines might help reduce this ambiguity. An immaterial breach, on the other hand, is the violation of a minor contractual obligation such that the essence of the deal is unaffected – notwithstanding the breach. A material breach “gets to the heart of the contract” in the sense that it would defeat the purpose of the contract (from the standpoint of the non-breaching party) if the breach were to remain unrectified. Definition of “Material Breach”Ī contract is a bargained-for exchange in which each party anticipates benefiting in some way. Whether a particular breach of contract is “material” or “immaterial” is a significant source of uncertainty – a non-breaching party is frequently unsure of whether it is entitled to terminate the contract. If the breach is immaterial, the other side is entitled to damages but is still bound to the contract. If the breach is material, the other side has the right to quit the contract immediately (and file a lawsuit for breach of contract). Paying your rent a day late, for example, might be seen as an immaterial breach while paying it two months late would probably be considered a material breach. A material breach is a serious breach, while an immaterial breach is not so serious. California contract law, however, distinguishes between “material” and “immaterial” breaches. You breach a contract by violating one of its terms. ![]() ![]() ![]() Make blow-trees with analogous colors. Drip a line of brownish watercolor on paper and blow it with a straw to make a trunk.With paint, have the children experiment with placing colors side by side in blocks and the different moods they create. Use a straw to blow bubbles in the cup and then make a bubble print with the different colors on white paper. Add food colors to dishwashing soap in a cup. Marble the paper in different color schemes. This can be done with crayons, colored pencils or pastels. Color each individual leaf of the other tree with different colors from the scheme. (Remind the children of the different seasons and kinds of trees – in other words, the whole color wheel is available to use.) Color the leaves in one tree all one color. Draw two simple trees with distinct leaves. Choose an analogous color scheme.Snakes Drawn in Analogous Colors (3rd Grade) art lesson.Analogous Color Weaving (3rd Grade) art lesson. ![]() Note that sometimes an artist may use a complement to the one of the analogous colors to make some object stand out. Ask them if the different analogous schemes produce clear feelings in the paintings.īook: Hop Jump, by Ellen Stoll Walsh (illustrations are in yellow to blue analogous colors.) Many book illustrations might be used. green through yellow to orange, or blue to purple, etc.) and whether the piece of analogous pie is big or small. First have them remove blacks, whites and browns. Start by making a triangle with red, yellow and blue, then add orange, purple and green and then other colors if they want. Then show them the images below. In each work of art, have the students identify where the analogous colors fit into the color wheel (i.e. Have students arrange crayons in a color wheel. Analogous colors schemes are like different pieces of pie – some are big, some are small. Teaching ideas: Show students the color wheel. Analogous color schemes often produce a strong “mood.” Analogous colors mean two or more colors that are side by side on the color wheel and often contain the same primary color (green, yellow, orange). Art Concept: Analogous Colors. Artists often use colors that are analogous. “Analogous” means near. ![]() |
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